Madrid hold a 3-1 advantage after defeating Chelsea for the first time in Europe and will be expected to finish off the job in the Spanish capital on Tuesday
Defeat in their first Champions League final means City remain without the biggest prize in European football despite billions of dollars being spent over the years by their Abu Dhabi owners.
While Barcelona celebrated, their victory removed the possibility of Chelsea winning both the men's and women's Champions League titles in the same season.
Real Madrid, 13-time record champions of Europe, will now try to salvage their season by emerging on top of a four-way battle for the Spanish domestic title.